Related Experiment Video
Updated: Dec 7, 2025
10:41
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
10.7K
Understanding the Interplay Between Health Disparities and Epigenomics
Viviana J Mancilla1, Noah C Peeri2, Talisa Silzer1
1Department of Microbiology, Immunology and Genetics, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX, United States.
Frontiers in Genetics
|September 25, 2020
Summary
Social epigenomics explores how socio-environmental factors impact human biology via epigenomic modifications, contributing to health disparities. Research now uses advanced molecular tech to study these environmental influences across the lifespan.
Area of Science:
- Integrative biology
- Social epigenomics
- Health disparities research
Background:
- Social epigenomics investigates socio-environmental factors influencing human biology and health disparities.
- Advances in molecular technologies enable deeper study of environmental impacts on epigenomic modifications like DNA methylation and micro-RNA expression.
- Existing research often uses genetic approaches, but epigenomic methods offer new insights.
Purpose of the Study:
- To review recent findings in social epigenomics.
- To examine the influence of socio-environmental factors on epigenomic modifications throughout the human lifespan.
- To highlight the connection between epigenomic changes and health disparities.
Main Methods:
- Review of recent scientific literature in social epigenomics.
- Analysis of studies focusing on epigenomic modifications (e.g., DNA methylation, micro-RNA expression).
- Examination of research across prenatal to adult developmental stages.
Main Results:
- Identification of key socio-environmental factors affecting epigenomic modifications.
- Understanding the role of epigenomic changes in contributing to health disparities.
- Exploration of potential epigenetic therapies and environmental strategies.
Conclusions:
- Social epigenomics is crucial for understanding health disparities.
- Epigenomic modifications are sensitive to environmental influences across the lifespan.
- Further research can inform targeted interventions to mitigate health inequities.
Related Concept Videos
01:20Gene-Environment Interactions
910
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
910
01:37Epigenetic Regulation
3.5K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.5K
01:46Epigenetic Regulation
33.0K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.0K
01:09Epistasis Analysis
5.5K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
5.5K
01:28Human Genetics
1.2K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.2K
02:30Genomic Imprinting and Inheritance
36.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.3K