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Phase 1 Clinical Trials in the Elderly: Enrollment Challenges
Carol Guarnieri1, Daniel D Von Hoff1
1HonorHealth Research Institute, Scottsdale, Arizona.
Journal of the Advanced Practitioner in Oncology
|September 25, 2020
Summary
Older adults are underrepresented in cancer clinical trials, limiting their access to new treatments. Strategies are needed to increase enrollment of elderly patients in oncology trials.
Area of Science:
- Oncology
- Geriatric Medicine
- Clinical Trials
Background:
- Cancer incidence increases with age, yet older adults are underrepresented in clinical trials.
- Clinical trials offer early access to novel cancer interventions and shape future treatments.
- Understanding barriers to enrollment for older adults in oncology trials is crucial.
Purpose of the Study:
- To identify barriers to older adult enrollment in oncology clinical trials.
- To compare tolerance, toxicity, and clinical benefit in elderly versus nonelderly populations.
- To advocate for increased enrollment of elderly patients in clinical trials.
Main Methods:
- Literature review comparing elderly and nonelderly patient outcomes in clinical trials.
- Analysis of barriers to enrollment for older adults in oncology studies.
- Discussion of strategies to enhance participation of older adults.
Main Results:
- Older adults face specific barriers to enrollment in oncology clinical trials.
- Data comparing outcomes between elderly and nonelderly patients in trials are summarized.
- Advanced practitioners can play a key role in advocating for elderly patient enrollment.
Conclusions:
- Increased enrollment of elderly patients in oncology clinical trials is essential.
- Strategies to overcome enrollment barriers are necessary for equitable access to cancer research.
- Health-care teams, particularly advanced practitioners, should advocate for elderly patients in phase I trials.
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