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Updated: Dec 7, 2025

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
Percutaneous closure of iatrogenic anterior mitral leaflet perforation: a case report
Hesham Abdo Naeim1, Osama Amoudi1, Abeer Mahmood1
1Madinah Cardiac Center, Adult Cardiology Department, Khaled Bin Waleed Street, PO 6167, Madinah, Saudi Arabia.
Background:
Severe mitral regurgitation (MR) through the body of the anterior mitral leaflet (AML) is rare. The cause either iatrogenic during open-heart surgery or due to infective endocarditis. We present a case where a successful percutaneous closure of the AML perforation was an alternative to surgery.
Case Summary:
A 60-year-old male presented with shortness of breath (SOB) class III of 12 months duration. He underwent coronary artery bypass surgery with four grafts plus mitral valve (MV) repair 20 months ago. Transthoracic echocardiogram (TTE) and transoesophageal echocardiogram (TOE) revealed severe MR through the body of AML at A3. The percutaneous closure plan was to cross the AML perforation from the left ventricular side. The venacontracta of the perforation was 6 mm, an amplatzer septal occluder device 6 mm considered appropriate for closure of this hole. A snare catheter snared the wire and exteriorized creating arteriovenous loop. Amplatzer septal occluder 6 mm loaded to the delivery system till larger disc (left-sided) opened safely and freely below the MV apparatus. Once the left ventricular side disc opposed the ventricular surface of AML, the waist and left atrial disc gently released. The patient discharged in the next day. After 6 months, the patient had no more SOB, he returned to his daily activity. Follow-up TTE showed no MR, the closure device was stable in place.
Discussion:
We added a successful case of transcatheter AML perforation to the literature. The role of TOE is crucial in diagnosis and procedure guidance.
Insights
A rare case of severe mitral regurgitation caused by anterior mitral leaflet perforation was successfully treated with a percutaneous closure device, avoiding surgery. This transcatheter approach offers a viable alternative for managing such complex cardiac conditions.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Severe mitral regurgitation (MR) from anterior mitral leaflet (AML) perforation is uncommon, often resulting from iatrogenic causes or infective endocarditis.
- This case highlights a rare instance of AML perforation following cardiac surgery.
Observation:
- A 60-year-old male with persistent shortness of breath post-coronary artery bypass graft and mitral valve repair presented with severe MR.
- Echocardiography confirmed a 6 mm perforation in the AML at the A3 segment.
Findings:
- Percutaneous closure of the AML perforation was performed using a 6 mm Amplatzer septal occluder device.
- The transcatheter procedure was successful, with the patient discharged the next day and symptom-free at 6-month follow-up.
Implications:
- Transcatheter closure of AML perforation is a feasible and effective alternative to surgical intervention.
- Transesophageal echocardiography (TOE) is critical for accurate diagnosis and procedural guidance in these cases.
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