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[Antibiotics sensitivity of "hospital" strains of S. typhimurium]

S Sh Rozhnova, V A Kilesso, E I Vydrina

    Antibiotiki
    |April 1, 1977
    PubMed

    Insights

    Hospital-acquired Salmonella Typhimurium strains show high antibiotic resistance, particularly to 7 of 9 tested antibiotics. However, all strains remained sensitive to gentamicin, indicating its potential effectiveness in treating infections.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Antimicrobial Resistance

    Background:

    • Hospital-acquired infections pose a significant public health challenge.
    • Salmonella Typhimurium is a common cause of bacterial infections, including hospital-acquired ones.
    • Understanding antibiotic resistance patterns is crucial for effective treatment strategies.

    Purpose of the Study:

    • To investigate the antibiotic sensitivity of Salmonella Typhimurium strains isolated from hospital infection settings.
    • To compare these strains with those from other sources and different Salmonella serogroups.
    • To identify potential therapeutic targets against resistant strains.

    Main Methods:

    • Isolation and serological typing of Salmonella Typhimurium strains.
    • Antibiotic susceptibility testing against a panel of 9 antibiotics.
    • Comparative analysis of resistance profiles based on isolation source and serogroup.

    Main Results:

    • Salmonella Typhimurium strains from hospital infections exhibited polyresistance to 7 out of 9 tested antibiotics.
    • All tested Salmonella strains demonstrated sensitivity to gentamicin.
    • Approximately 50% of the strains were sensitive to polymyxin M.

    Conclusions:

    • Salmonella strains causing hospital outbreaks display significant multidrug resistance.
    • Gentamicin remains a consistently effective antibiotic against these strains.
    • Polymyxin M shows moderate effectiveness, warranting further investigation.

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