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Hepatitis E Virus and rheumatic diseases: what do rheumatologists need to know?
Salvatore Di Bartolomeo1,2, Francesco Carubbi1,2, Paola Cipriani1
1Rheumatology Unit, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, L'Aquila, Italy.
BMC Rheumatology
|September 25, 2020
Summary
Hepatitis E virus (HEV) infection can cause rheumatic symptoms, complicating diagnosis and treatment for rheumatologists. Further research is needed to understand HEV
Area of Science:
- Hepatology
- Rheumatology
- Infectious Diseases
Background:
- Hepatitis E virus (HEV) is a global cause of acute hepatitis, often transmitted via undercooked pork.
- HEV infection is linked to extra-hepatic manifestations and severe liver failure in immunocompromised individuals.
- HEV can mimic rheumatic diseases (RDs) or drug toxicity, complicating clinical management.
Purpose of the Study:
- To review rheumatic manifestations associated with HEV infection.
- To discuss the implications of HEV for rheumatologists in clinical practice.
- To highlight knowledge gaps regarding HEV in patients with rheumatic diseases and under immunosuppressive therapy.
Main Methods:
- Literature review of rheumatic manifestations of HEV infection.
- Analysis of existing data on HEV course in rheumatic disease patients.
- Examination of HEV's impact on immunosuppressive drug therapy.
Main Results:
- HEV infection presents with diverse extra-hepatic manifestations, including rheumatic symptoms.
- Limited data exists on HEV's impact on patients with rheumatic diseases, especially those on immunosuppressants.
- HEV can mimic rheumatic disease flares or adverse drug reactions.
Conclusions:
- More research is essential to clarify the clinical outcomes and optimal management of HEV infection in patients with rheumatic diseases.
- Understanding HEV's interaction with rheumatic diseases and immunosuppressive therapies is crucial for improved patient care.
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