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Related Experiment Videos

Implantable pumps.

M V Sefton

    Critical Reviews in Biomedical Engineering
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Implantable drug-delivery pumps offer external control for precise medication administration, enhancing treatment for conditions like diabetes and cancer. These advanced systems provide controlled or variable drug release beyond conventional methods.

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    Area of Science:

    • Biomedical Engineering
    • Pharmacology
    • Medical Devices

    Background:

    • Conventional controlled-release formulations have limitations in drug delivery volumes and rate control.
    • Implantable drug-delivery pumps are emerging as a solution for precise and advanced medication administration.
    • Key applications include insulin delivery for diabetes and chemotherapeutic agents for cancer treatment.

    Purpose of the Study:

    • To review the development and applications of implantable drug-delivery pumps.
    • To highlight devices offering external control over delivery rates.
    • To discuss pumps capable of delivering volumes beyond conventional formulations.

    Main Methods:

    • Review of existing literature on implantable drug-delivery pump technology.

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  • Description of the Infusaid pump's mechanism (fluorocarbon vapor-liquid mixture).
  • Discussion of implantable peristaltic pumps with transcutaneous telemetry for variable rate delivery.

    • Main Results:

    • The Infusaid pump provides a constant drug delivery rate.
    • Implantable peristaltic pumps allow for physician-preprogrammed, variable drug delivery rates.
    • Various other devices are documented in scientific literature, though not all are in clinical use.

    Conclusions:

    • Implantable drug-delivery pumps offer significant advantages in controlling drug administration.
    • These devices expand therapeutic possibilities for chronic diseases and complex treatments.
    • Ongoing innovation is leading to more sophisticated and versatile drug delivery systems.