Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....

Protein Organization

Protein Organization

Protein Folding

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...

Protein Folding

Protein Folding

Protein and Protein Structure

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...

Protein and Protein Structures

Protein and Protein Structures

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The effect of vigorous physical activity on the incidence of kidney cancer.

Cancer epidemiology·2026

Same author

Perceived impact of field trips on students' sense of community, skills and knowledge in Biosciences and Chemistry undergraduate degrees.

Emerging topics in life sciences·2026

Same author

Obesity, metformin prescription and risk of advanced prostate cancer in non-diabetic men.

BJC reports·2026

Same author

Longitudinal study of changing inspirations and aspirations of first-year students before and after the Covid-19 pandemic.

Emerging topics in life sciences·2026

Same author

Global, regional, and national burden of hepatocellular carcinoma and contribution of nine modifiable risk factors across 185 countries/territories in 2022.

Science bulletin·2026

Same author

Peer group social media interactions within a blended learning space.

Emerging topics in life sciences·2026

Same journal

Intra- and inter-biosynthetic gene cluster allelic variation as drivers of chemical diversification in Streptomyces.

Essays in biochemistry·2026

Same journal

Considering internal conflict in the face of natural product biosynthesis and biosynthetic gene cluster evolution.

Essays in biochemistry·2026

Same journal

The plant holobiont: integrating molecular priming and ecological legacies for climate-adaptive immunity.

Essays in biochemistry·2026

Same journal

Bacterial-fungal interactions: connections and consequences.

Essays in biochemistry·2026

Same journal

Invasive plasmids as ecosystem engineers-from mechanism to application.

Essays in biochemistry·2026

Same journal

From early defence priming to lasting memory: developmental and seasonal dynamics in trees.

Essays in biochemistry·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 7, 2025

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Uncovering protein structure.

Elliott J Stollar¹, David P Smith²

¹School of Life Sciences, University of Liverpool, Liverpool, United Kingdom.

Essays in Biochemistry

|September 25, 2020

Summary

This summary is machine-generated.

Structural biology explores protein structure and dynamics, explaining molecular function through chemistry and physics. This review details protein folding, thermodynamics, dynamics, and methods used to uncover these vital molecular structures.

Keywords:

protein binding protein chemistry protein conformation protein structure

More Related Videos

Author Spotlight: Advancing Protein Structure Analysis for Drug Development

Author Spotlight: Advancing Protein Structure Analysis for Drug Development

Published on: March 8, 2024

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Related Experiment Videos

Last Updated: Dec 7, 2025

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Author Spotlight: Advancing Protein Structure Analysis for Drug Development

Author Spotlight: Advancing Protein Structure Analysis for Drug Development

Published on: March 8, 2024

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Area of Science:

Structural biology
Biochemistry
Molecular dynamics

Background:

Proteins are fundamental to life processes.
Understanding protein structure is key to understanding protein function.
Protein structural biology offers atomic-level insights into molecular mechanisms.

Purpose of the Study:

To provide an overview of protein structure and the principles governing it.
To explain the chemistry and physics underlying protein structure determination.
To review the methods used in protein structural biology.

Main Methods:

Exploration of amino acid chemistry and interactions.
Analysis of the four levels of protein structure.
Consideration of protein folding thermodynamics and dynamics.
Description of experimental techniques for structure elucidation.

Main Results:

Proteins fold into specific structures driven by thermodynamics.
Misfolding can occur, impacting protein function.
Proteins exhibit dynamics, existing in multiple conformations.
Various biochemical methods reveal protein structure and properties.

Conclusions:

Structural biology provides critical atomic-level detail of life's fundamental molecules.
Understanding protein structure is essential for explaining biological functions.
The field is advancing, promising deeper insights into molecular processes.