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Conditioned Place Preference (CPP) in Rats: From Conditioning to Reinstatement Test.

Maria Scherma1, Liana Fattore2, Walter Fratta3,4

  • 1Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Cagliari, Italy.

Methods in Molecular Biology (Clifton, N.J.)
|September 25, 2020
PubMed
Summary

Opioid addiction is a relapsing disorder with high relapse rates. The morphine-conditioned place preference (CPP) model aids in studying drug reward effects in preclinical research.

Keywords:
AddictionAnimal modelConditioned place preferenceOpioid abuse

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Addiction Research

Background:

  • Opioid addiction is a chronic, relapsing disorder with significant public health implications.
  • Understanding the neurobiology of addiction is crucial for developing effective treatments.
  • Animal models are vital for investigating addiction mechanisms and identifying therapeutic targets.

Purpose of the Study:

  • To describe the morphine-conditioned place preference (CPP) model for preclinical addiction research.
  • To highlight the utility of the CPP model in studying drug-related effects.
  • To provide a step-by-step guide for implementing the CPP model.

Main Methods:

  • The chapter details the morphine-conditioned place preference (CPP) model.
  • This preclinical model assesses the rewarding and aversive effects of drugs.
  • Methodology involves establishing associations between drug administration and specific environments.

Main Results:

  • The CPP model effectively measures the rewarding or aversive properties of drugs like morphine.
  • This model allows for the investigation of specific components of addiction.
  • Results from CPP studies can inform the identification of potential therapeutic targets.

Conclusions:

  • The morphine-conditioned place preference (CPP) model is a valuable preclinical tool for addiction research.
  • It aids in understanding the neurobiological underpinnings of drug reward and relapse.
  • The CPP model facilitates the discovery of novel therapeutic strategies for opioid addiction.