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Updated: Dec 7, 2025
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Determining Ultrasonic Vocalization Preferences in Mice using a Two-choice Playback Test
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Evaluation of μ-Opioid System Functionality in Mouse Pups: Ultrasonic Vocalizations as an Index of Infant Attachment
1Institute of Biochemistry and Cellular Biology, National Research Council, Rome, Italy. francesca.damato@cnr.it.
Methods in Molecular Biology (Clifton, N.J.)
|September 25, 2020
Abstract:
The evaluation of ultrasonic vocalizations (USVs) during isolation in 6-8-day-old mouse pups can give an indication of the perception of pups' discomfort and need for caretaker presence to overcome the unpleasant condition. Time spent vocalizing changed according to opioid activation, stress exposure, and genetic profile of pups. Deficits in attachment suggest altered opioid functioning and predisposal for long-term defective social behaviors and reward processes.
