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T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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Related Experiment Video

Updated: Dec 7, 2025

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

Engineered Th17 Cell Differentiation Using a Photoactivatable Immune Modulator.

Bibudha Parasar, Pamela V Chang

Journal of the American Chemical Society

|September 25, 2020

Summary

This summary is machine-generated.

Researchers developed a photoactivatable immune modulator (PIM) to precisely control T helper 17 (Th17) cell differentiation. This tool allows on-demand modulation of Th17 cells, aiding the study of immune responses and inflammatory diseases.

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Last Updated: Dec 7, 2025

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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

Area of Science:

Immunology
Synthetic Biology
Chemical Biology

Background:

T helper 17 (Th17) cells are crucial for combating extracellular pathogens.
Regulation and plasticity of Th17 cells remain poorly understood.
Understanding Th17 cell dynamics is vital for immunity and disease research.

Purpose of the Study:

To develop a precise method for controlling Th17 cell differentiation.
To investigate the dynamic functions and behaviors of Th17 cells.
To elucidate the regulation and plasticity of Th17 cell populations.

Main Methods:

Developed a photoactivatable immune modulator (PIM).
Utilized a latent agonist that releases an aryl hydrocarbon receptor (AhR) ligand upon photochemical activation.
Employed UV light for spatiotemporal control of AhR activation and Th17 differentiation.

Main Results:

Demonstrated precise spatial and temporal control over Th17 cell differentiation.
Successfully modulated Th17 cell induction on demand using the PIM system.
Established a novel chemical tool for studying immune cell plasticity.

Conclusions:

The PIM approach offers unprecedented control over Th17 cell differentiation.
This method facilitates in-depth study of Th17 cell dynamics in immune responses.
Enables further research into Th17 cell roles in inflammatory disease models.