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Increased Longevity and Pumping Performance of an Injection Molded Soft Total Artificial Heart.

Leonard G Guex1, Lewis S Jones1, A Xavier Kohll1

  • 1Department of Chemistry and Applied Biosciences, Institute for Chemical- and Bioengineering, ETH Zurich, Zurich, Switzerland.

Soft Robotics
|September 25, 2020
PubMed
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Researchers developed an injection molded soft total artificial heart (sTAH) from silicone. This sTAH achieved over 16 L/min cardiac output and ran for 110,000 cycles in testing.

Area of Science:

  • Biomedical Engineering
  • Materials Science

Background:

  • Total artificial hearts (TAHs) are crucial for end-stage heart failure.
  • Current TAH designs face challenges in biocompatibility, durability, and manufacturing.

Purpose of the Study:

  • To develop and evaluate a novel injection molded soft total artificial heart (sTAH).
  • To assess the performance and durability of the sTAH under physiological conditions.

Main Methods:

  • Utilized high-temperature vulcanizing silicone and industrial metal injection molding for sTAH fabrication.
  • Conducted mock circulation testing at 60 beats per minute against physiological pressures.
  • Employed finite element analysis (FEA) to identify stress concentrations and guide design optimization.

Main Results:

Keywords:
circulatory supportinjection moldingsoft pumptotal artificial heart

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  • The sTAH demonstrated a total cardiac output exceeding 16 L/min.
  • Continuous pumping for 110,000 actuation cycles was achieved, indicating significant durability.
  • FEA identified critical stress areas, informing design improvements.

Conclusions:

  • Injection molding offers a viable manufacturing method for soft TAHs.
  • The developed sTAH shows promising performance and durability for potential clinical application.
  • FEA is a valuable tool for optimizing sTAH design and enhancing longevity.