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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Hazard Ratio01:12

Hazard Ratio

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The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Blinding01:11

Blinding

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Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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Types of Reports III: Telephone and Verbal Reports01:26

Types of Reports III: Telephone and Verbal Reports

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Telephone and Verbal Reports in healthcare settings are two communication methods for conveying therapeutic instructions from healthcare providers to nurses or other healthcare staff.
Here's an overview of each type:
Telephone Orders
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Guidelines for reporting randomized controlled trials in paediatric dentistry based on the CONSORT statement.

Jayakumar Jayaraman1

  • 1Department of Developmental Dentistry, University of Texas Health School of Dentistry, San Antonio, TX, USA.

International Journal of Paediatric Dentistry
|September 25, 2020
PubMed
Summary

This study highlights the importance of the Consolidated Standards of Reporting Trials (CONSORT) guidelines for accurate randomized controlled trial (RCT) reporting in pediatric dentistry. Adherence ensures transparency in trial design, analysis, and results.

Keywords:
CONSORTguidelinespaediatric dentistryrandomizedreportingtrials

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Area of Science:

  • Clinical Trials Methodology
  • Scientific Reporting Standards
  • Paediatric Dentistry Research

Background:

  • Accurate and transparent reporting of randomized controlled trials (RCTs) is crucial for their scientific validity.
  • The Consolidated Standards of Reporting Trials (CONSORT) statement aims to improve RCT reporting quality.
  • Despite CONSORT recommendations, the overall reporting quality of RCTs remains suboptimal.

Purpose of the Study:

  • To emphasize the significance of CONSORT reporting guidelines in paediatric dentistry research.
  • To provide explanations and examples for CONSORT checklist items using published paediatric dentistry RCTs.
  • To enhance the accuracy and transparency of RCT reporting in the field.

Main Methods:

  • A narrative review approach was employed to illustrate the importance of CONSORT items.
  • RCTs published in the International Journal of Paediatric Dentistry (2017-2020) were identified via database searches and handsearching.
  • Explanations were provided for all 37 items of the 2010 CONSORT checklist and 17 items of the CONSORT extension for abstracts.

Main Results:

  • The review details the 37 core CONSORT checklist items and 17 CONSORT abstract extension items.
  • Examples from paediatric dentistry RCTs illustrate the practical application and importance of each reporting item.
  • The study underscores the need for comprehensive adherence to CONSORT guidelines.

Conclusions:

  • This detailed explanation of CONSORT guidelines will assist investigators in reporting paediatric dentistry RCTs accurately and transparently.
  • The document serves as a valuable resource for reviewers and editors in assessing the quality of published RCTs.
  • Improved adherence to CONSORT guidelines will enhance the reliability and interpretability of paediatric dentistry research findings.