Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

6.2K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.2K
Tumor Progression02:07

Tumor Progression

7.0K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction of "Nanoscale Donor-Acceptor Covalent Organic Frameworks for Mitochondria-Targeted Sonodynamic Therapy and Antitumor Immunity".

Journal of the American Chemical Society·2026
Same author

Cutaneous T-cell lymphoma tumors undergoing radiotherapy demonstrate immune shifts from malignant inflammation to wound healing and suggest markers of treatment durability.

Journal of the American Academy of Dermatology·2026
Same author

Radiation Oncology-Biology Integration Network: Bridging the Gap between Biological Research and Clinical Practice.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

m <sup>6</sup> A-dependent microRNA binding to chromatin-associated RNA for transcriptional activation.

bioRxiv : the preprint server for biology·2026
Same author

The OligoPanc project: an interdisciplinary expert consensus statement on oligometastatic pancreatic cancer.

The Lancet. Oncology·2026
Same author

IFN signaling at the nexus of the radiotherapy response in malignant peripheral nerve sheath tumors.

The Journal of clinical investigation·2026

Related Experiment Video

Updated: Dec 7, 2025

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
13:04

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

Published on: October 14, 2015

13.6K

Oligometastasis: Past, Present, Future.

Stanley I Gutiontov1, Sean P Pitroda1, Ralph R Weichselbaum1

  • 1Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois.

International Journal of Radiation Oncology, Biology, Physics
|September 25, 2020
PubMed
Summary
This summary is machine-generated.

The oligometastatic state is a transitional phase of cancer spread. Molecular features are key to refining its definition and improving radiation therapy for better patient outcomes.

More Related Videos

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
11:43

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Published on: November 30, 2016

13.2K
Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
09:44

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

8.7K

Related Experiment Videos

Last Updated: Dec 7, 2025

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
13:04

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

Published on: October 14, 2015

13.6K
Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
11:43

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Published on: November 30, 2016

13.2K
Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
09:44

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

8.7K

Area of Science:

  • Oncology
  • Radiation Therapy
  • Translational Medicine

Background:

  • The understanding of metastatic disease is evolving, moving beyond a binary view to a spectrum.
  • The oligometastatic hypothesis suggests a distinct intermediate state between localized and widespread metastasis.
  • Clinical criteria for defining oligometastatic disease have limitations, necessitating refined diagnostic approaches.

Purpose of the Study:

  • To review the current and future relevance of the oligometastatic state in radiation therapy.
  • To discuss the clinical data supporting the oligometastatic hypothesis and its limitations.
  • To explore the role of molecular features in refining the definition and treatment of oligometastatic disease.

Main Methods:

  • Review of clinical data and radiation therapy literature.
  • Discussion of preclinical and translational research on molecular features.
  • Analysis of genomic, epigenetic, and immunologic correlates of oligometastatic disease.

Main Results:

  • Ablative radiation therapy shows benefits in cancer-specific outcomes for oligometastatic disease, particularly in non-small cell lung and prostate cancers.
  • Improved imaging technologies enhance the detection of occult metastatic disease.
  • Molecular features (genomic, epigenetic, immunologic) combined with clinical factors improve prognostication.

Conclusions:

  • Refining the definition of oligometastatic disease using molecular features is crucial for advancing radiation therapy.
  • Therapeutic manipulation of molecular targets may revert the polymetastatic to oligometastatic phenotype.
  • Further research and support for these inquiries are vital for future clinical practice and trials in radiation oncology.