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LncRNA regulation: New frontiers in epigenetic solutions to drug chemoresistance

Ying Zhou1, Wen Sun1, Zhiyuan Qin1

  • 1Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Biochemical Pharmacology
|September 25, 2020
PubMed

Insights

Long non-coding RNAs (lncRNAs) interact with epigenetic regulators to influence cancer drug resistance. Understanding these interactions offers new targets to reverse resistance and improve cancer therapy outcomes.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Long non-coding RNAs (lncRNAs) modulate cancer cell sensitivity to chemotherapy.
  • lncRNAs are linked to epigenetic regulators, influencing gene transcription via histone modification and DNA methylation.
  • This lncRNA-epigenetic interplay can drive cancer drug resistance.

Purpose of the Study:

  • To review the role of lncRNAs in cancer drug resistance.
  • To highlight epigenetic signatures as biomarkers for therapeutic monitoring.
  • To explore lncRNA-epigenetic mechanisms as targets for overcoming drug resistance.

Main Methods:

  • Literature review of lncRNA and epigenetics in cancer drug resistance.
  • Discussion of epigenetic mechanisms (histone modification, DNA methylation).
  • Presentation of computational tools and network analysis for lncRNA expression.

Main Results:

  • lncRNAs associated with epigenetic controllers can induce drug resistance by regulating core genes.
  • Epigenetic signatures are dynamic, inheritable, and reversible biomarkers.
  • Computational tools aid in identifying correlations between lncRNAs and biomolecules.

Conclusions:

  • The lncRNA-epigenetic machinery interaction is a promising target to reverse cancer drug resistance.
  • lncRNA network analysis provides a framework for identifying therapeutic targets.
  • Epigenetic biomarkers offer insights into treatment efficacy.
Keywords:
Bioinformatics toolsChemoresistanceEpigeneticsLncRNA

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