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Nanocarriers for effective nutraceutical delivery to the brain
Rugmani Meenambal1, M M Srinivas Bharath2
1Department of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India.
Neurochemistry International
|September 25, 2020
Summary
Plant-derived nutraceuticals show promise for neurodegenerative disorders but face delivery challenges. Nanoparticle conjugation enhances brain bioavailability and therapeutic efficacy, offering a novel approach for treating these conditions.
Area of Science:
- Neuroscience
- Pharmacology
- Biotechnology
Background:
- Neurodegenerative disorders affect aging populations globally, characterized by neuronal loss and inflammation.
- Conventional pharmacotherapy offers limited success due to various factors.
- Plant-derived nutraceuticals show therapeutic potential in preclinical models of neurodegeneration.
Purpose of the Study:
- To review advances in nanoparticle-conjugated nutraceuticals for neurodegenerative disorders.
- To discuss the advantages, limitations, clinical trials, and toxicity of these novel delivery systems.
Main Methods:
- Literature review of research on nanoparticle-conjugated nutraceuticals.
- Analysis of studies focusing on enhanced bioavailability and blood-brain barrier (BBB) penetration.
- Evaluation of preclinical and clinical trial data.
Main Results:
- Nutraceuticals often fail in human trials due to poor bioavailability and limited BBB permeability.
- Nanoparticle conjugation significantly enhances the delivery and efficacy of nutraceuticals to the brain.
- This approach addresses key limitations of conventional nutraceutical therapy.
Conclusions:
- Nanoparticle-conjugated nutraceuticals represent a promising strategy for treating neurodegenerative diseases.
- Further research is needed to address clinical trial outcomes and potential toxicity concerns.
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