Fibrinogen: A potential biomarker for predicting disease severity in multiple sclerosis

Area of Science:

• Neuroimmunology
• Biochemistry

Background:

• Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with unknown pathogenesis.
• Fibrinogen's potential role in MS pathology requires elucidation.
• Investigating fibrinogen as a biomarker for disease management is crucial.

Purpose of the Study:

• To elucidate the role of fibrinogen in multiple sclerosis (MS) pathology.
• To discuss fibrinogen's candidacy as a biomarker for MS disease management.

Main Methods:

• A systematic literature review was conducted.
• The PubMed biomedical database was utilized for the literature search.

Main Results:

• Fibrinogen's role in disease development has been extensively studied.
• Clinical application of fibrinogen as a viable biomarker is not yet conclusively achieved in human studies.

Conclusions:

• Emerging evidence suggests fibrinogen and its degradation products may be involved in MS pathogenesis.
• Further research is necessary to evaluate fibrinogen as a practical biomarker for diagnosis or disease severity assessment.