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Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar

Dai Matsuse1, Ryo Yamasaki1, Guzailiayi Maimaitijiang1

  • 1Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Journal of Neuroimmunology
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Summary

A decrease in intermediate monocytes in peripheral blood is a key biomarker for identifying multiple system atrophy-cerebellar type (MSA-C). This finding aids in early diagnosis and understanding disease progression.

Keywords:
BiomarkerIntermediate monocyteMonocyteMultiple system atrophySurface marker

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Area of Science:

  • Neuroscience
  • Immunology
  • Biomarker Discovery

Background:

  • Multiple system atrophy-cerebellar type (MSA-C) is a neurodegenerative disorder with limited diagnostic biomarkers.
  • Peripheral blood monocyte subsets may offer insights into neuroinflammatory processes in MSA-C.

Purpose of the Study:

  • To identify novel peripheral blood biomarkers for early diagnosis of MSA-C.
  • To investigate differences in monocyte surface marker expression between MSA-C patients, hereditary spinocerebellar degeneration (hSCD) patients, and healthy controls (HCs).

Main Methods:

  • Flow cytometry was employed to quantify surface marker expression on peripheral blood monocytes.
  • Monocyte populations, including intermediate monocytes and CD62L+ intermediate monocytes, were analyzed in MSA-C, hSCD, and HC groups.

Main Results:

  • The percentage of intermediate monocytes was significantly reduced in MSA-C patients compared to hSCD patients and HCs.
  • Reduced intermediate monocyte percentage positively correlated with disease duration and Unified MSA Rating Scale scores in MSA-C patients.
  • The expression of CD62L on intermediate monocytes was also significantly lower in MSA-C patients.

Conclusions:

  • An early decrease in peripheral blood intermediate monocytes is a characteristic feature of MSA-C.
  • Intermediate monocytes represent a potential diagnostic biomarker for MSA-C, aiding in early detection.