Related Experiment Video
Updated: Dec 7, 2025

Conversion of Human Induced Pluripotent Stem Cells iPSCs into Functional Spinal and Cranial Motor Neurons Using PiggyBac Vectors
Published on: May 1, 2019
Development of a human iPSC line (SMBCi004-A) from a patient with Gaucher disease
Qingyang Zhao1, Yazhou Cui1, Jing Wang1
1Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji'nan 250014, Shandong, China; Biomedical Sciences College, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji'nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji'nan 250062, Shandong, China.
Abstract:
A human induced pluripotent stem cell (iPSC) line was generated from the urine cells of a 8-year-old female with Gaucher disease with the homozygous changes c.1448 T>C in the GBA gene. Reprogramming factors OCT4, SOX2, KLF4, and miR-302-367 were delivered using a non-integrative plasmid. Our iPSCs showed complete pluripotency, normal genetic stability, and the ability to differentiate into three germ layers.
More Related Videos
09:34Automated Production of Human Induced Pluripotent Stem Cell-Derived Cortical and Dopaminergic Neurons with Integrated Live-Cell Monitoring
Published on: August 6, 2020
10:59Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein
Published on: June 6, 2025