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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Mitochondria01:37

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Replicative Cell Senescence02:15

Replicative Cell Senescence

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Related Experiment Video

Updated: Dec 7, 2025

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
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Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis.

Gisela Machado-Oliveira1, Cristiano Ramos1, André R A Marques1

  • 1CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.

Cells
|September 26, 2020
PubMed
Summary
This summary is machine-generated.

Cellular senescence contributes to atherosclerosis development. Targeting senescent cells with senolytic drugs may offer future treatments for cardiovascular diseases, but more research is needed.

Keywords:
atherosclerosiscardiovascular diseasessenescencesenescent organelles

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Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Cell Biology

Background:

  • Atherosclerosis is an age-related cardiovascular disease driven by risk factors, leading to heart attacks and strokes.
  • Cellular senescence, a process of cellular aging, is increasingly recognized for its role in the development of atherosclerosis.
  • Understanding the link between senescence and atherogenesis is crucial for developing new treatments.

Purpose of the Study:

  • To review the impact of senescence on intracellular organelles in atherosclerosis.
  • To analyze the roles of different cell types in senescence and atherogenesis.
  • To provide an updated overview of therapeutic strategies, including senolytic drugs, for cardiovascular disease.

Main Methods:

  • Literature review focusing on senescence-related alterations in intracellular organelles.
  • Analysis of cell-type-specific contributions to senescence and atherogenesis.
  • Review of current and experimental therapeutic approaches for atherosclerosis.

Main Results:

  • Senescence induces significant changes in major intracellular organelles, impacting cellular function in the context of atherosclerosis.
  • Specific cell types play critical roles in the interplay between senescence and the progression of atherosclerotic plaques.
  • Senolytic drugs show promise in preclinical studies for counteracting atherosclerosis by clearing senescent cells.

Conclusions:

  • Cellular senescence is a key factor in the pathogenesis of atherosclerosis.
  • Targeting senescence pathways and clearing senescent cells represent promising therapeutic avenues for cardiovascular disease.
  • Further research is necessary to fully elucidate the mechanisms of senescence in atherogenesis and optimize senolytic therapies.