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Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine
Zarema Gilazieva1, Aleksei Ponomarev1, Catrin Rutland2
1Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Abstract:
One of the promising directions in personalized medicine is the use of three-dimensional (3D) tumor models such as spheroids and organoids. Spheroids and organoids are three-dimensional cultures of tumor cells that can be obtained from patient tissue and, using high-throughput personalized medicine methods, provide a suitable therapy for that patient. These 3D models can be obtained from most types of tumors, which provides opportunities for the creation of biobanks with appropriate patient materials that can be used to screen drugs and facilitate the development of therapeutic agents. It should be noted that the use of spheroids and organoids would expand the understanding of tumor biology and its microenvironment, help develop new in vitro platforms for drug testing and create new therapeutic strategies. In this review, we discuss 3D tumor spheroid and organoid models, their advantages and disadvantages, and evaluate their promising use in personalized medicine.
Insights
Three-dimensional (3D) tumor models like spheroids and organoids offer personalized medicine solutions by enabling patient-specific drug screening and advancing tumor biology understanding. These models are crucial for developing targeted therapies.
Area of Science:
- Oncology
- Biotechnology
- Personalized Medicine
Background:
- Three-dimensional (3D) tumor models, including spheroids and organoids, are emerging as powerful tools in personalized medicine.
- These models are derived from patient tumor tissues, offering a more accurate representation of individual tumors compared to traditional 2D cultures.
Purpose of the Study:
- To review the current state of 3D tumor spheroid and organoid models.
- To discuss their advantages, disadvantages, and potential applications in personalized medicine.
- To highlight their role in advancing drug screening and understanding tumor biology.
Main Methods:
- Review of existing literature on 3D tumor models (spheroids and organoids).
- Analysis of the benefits and limitations of these models for personalized therapy.
- Evaluation of their utility in biobanking and high-throughput drug screening.
Main Results:
- 3D tumor models can be generated from most tumor types, facilitating biobank creation.
- These models enhance the understanding of tumor biology and the tumor microenvironment.
- They provide a platform for effective in vitro drug testing and development of novel therapeutic strategies.
Conclusions:
- 3D tumor models represent a significant advancement in personalized medicine.
- Their application in drug screening and therapeutic development holds great promise.
- Continued research into spheroids and organoids will likely accelerate the development of tailored cancer treatments.
