Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peptides and epithelial growth regulation.

R A Goodlad, N A Wright

    Experientia
    |July 15, 1987
    PubMed
    Summary

    Several peptides regulate gastrointestinal epithelial cell proliferation. Epidermal growth factor (EGF) shows a powerful trophic response throughout the gut, indicating its significant role in gut health and renewal.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Does human endometrial LGR5 gene expression suggest the existence of another hormonally regulated epithelial stem cell niche?

    Human reproduction (Oxford, England)·2018
    Same author

    Novel application of high-dose rate brachytherapy for severe, recalcitrant palmoplantar pustulosis.

    Clinical and experimental dermatology·2016
    Same author

    The stem cells of small intestinal crypts: where are they?

    Cell proliferation·2009
    Same author

    APC and the three-hit hypothesis.

    Oncogene·2008
    Same author

    Exogenous bone marrow cells do not rescue non-irradiated mice from acute renal tubular damage caused by HgCl2, despite establishment of chimaerism and cell proliferation in bone marrow and spleen.

    Cell proliferation·2008
    Same author

    Haematopoietic lineage-committed bone marrow cells, but not cloned cultured mesenchymal stem cells, contribute to regeneration of renal tubular epithelium after HgCl 2 -induced acute tubular injury.

    Cell proliferation·2008

    Area of Science:

    • Gastroenterology
    • Cell Biology
    • Endocrinology

    Background:

    • Gastrointestinal epithelial cell proliferation and renewal are crucial for gut function.
    • Several peptides are implicated in regulating these processes, often linked to food intake and digestion.
    • The precise roles of specific peptides, like gastrin and enteroglucagon, in gut epithelial regulation require further elucidation.

    Purpose of the Study:

    • To review the evidence for various peptides involved in controlling gastrointestinal epithelial cell proliferation.
    • To highlight the trophic effects of epidermal growth factor (EGF) demonstrated through recent studies.
    • To emphasize the need for further in vivo evaluation of peptide roles in gut health.

    Main Methods:

    • Review of existing scientific literature on peptide regulation of gastrointestinal cell proliferation.
    • Analysis of studies investigating the effects of specific peptides, including gastrin, enteroglucagon, peptide YY, bombesin, and EGF.
    • Consideration of data from experiments using recombinant epidermal growth factor (EGF) infusion.

    Main Results:

    • Gastrin is trophic to the stomach, but its broader gastrointestinal role is debated.
    • Enteroglucagon is circumstantially associated with increased intestinal epithelial proliferation.
    • Infused epidermal growth factor (EGF) elicits a potent trophic response across the entire gastrointestinal tract.

    Conclusions:

    • Peptides play a significant role in regulating gastrointestinal epithelial cell proliferation and renewal.
    • Epidermal growth factor (EGF) demonstrates a powerful, direct trophic effect on the gut epithelium.
    • Increased availability of peptides will facilitate rigorous in vivo studies to confirm their trophic roles in the gastrointestinal tract.

    Related Experiment Videos