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Mesenchymal Stem Cells01:19

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Mesenchymal Stem Cells Current Clinical Applications: A Systematic Review.

David E Rodríguez-Fuentes1, Luis E Fernández-Garza2, John A Samia-Meza1

  • 1Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Monterrey, NL, México.

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|September 26, 2020
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Human Mesenchymal Stem Cells (hMSCs) show broad therapeutic potential across many clinical settings. Ongoing trials indicate promising results with no serious adverse events, highlighting their value in regenerative medicine.

Keywords:
Clinical trialMedicinal signaling cellsMesenchymal stem cells

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Area of Science:

  • Stem Cell Biology
  • Regenerative Medicine
  • Clinical Trials

Background:

  • Human Mesenchymal Stem Cells (hMSCs) are multipotent cells with regenerative and immunomodulatory properties.
  • hMSCs can differentiate into various tissues and secrete factors that promote tissue repair.
  • Numerous clinical trials are investigating hMSC therapeutic applications.

Purpose of the Study:

  • To review the landscape of clinical trials involving hMSCs.
  • To analyze the characteristics and outcomes of completed hMSC clinical trials.

Main Methods:

  • A systematic search of clinicaltrials.gov using the term "Mesenchymal Stem Cells".
  • Inclusion and exclusion criteria were applied in two stages, focusing on trial phases, fields, and published outcomes.
  • Data extracted included trial phase, application field, intervention details, cell source, preparation, and results.

Main Results:

  • Over 1,138 clinical trials were registered by July 2020, predominantly in Phase 2 (61.0%) and Phase 1 (30.8%).
  • Key application areas include traumatology, neurology, cardiology, and immunology.
  • Of 18 trials with published results, bone marrow was the most common source, treatments ranged from 1-200 million cells, and all reported positive outcomes with no serious adverse effects.

Conclusions:

  • hMSCs demonstrate significant potential for clinical applications with a favorable safety profile.
  • Ongoing clinical trials are expected to further elucidate the therapeutic benefits of hMSCs.
  • hMSCs represent a promising source of medicinal signals for tissue repair and immune modulation.