Related Experiment Video
Updated: Dec 7, 2025
05:16
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
3.6K
Sporadic pregnancy loss and recurrent miscarriage
Adam J Devall1, Arri Coomarasamy1
1Tommy's National Centre for Miscarriage Research, College of Medical and Dental Sciences, University of Birmingham, UK.
Best Practice & Research. Clinical Obstetrics & Gynaecology
|September 26, 2020
Summary
Vaginal micronized progesterone may help prevent miscarriage in women experiencing early pregnancy bleeding, especially those with a history of miscarriage. This treatment offers potential benefits for threatened and recurrent miscarriage cases.
Area of Science:
- Reproductive endocrinology
- Obstetrics and Gynecology
- Pharmacology
Background:
- Progesterone is crucial for maintaining pregnancy.
- Progesterone deficiency is linked to miscarriage.
- The efficacy of progesterone supplementation for preventing miscarriage has been debated for over 70 years.
Purpose of the Study:
- To review existing evidence on progesterone supplementation for miscarriage prevention.
- To present the latest research on micronized natural progesterone and synthetic progestogens.
- To evaluate treatments for recurrent and threatened miscarriage.
Main Methods:
- Comprehensive review of historical and recent medical literature.
- Analysis of studies using various progestogens, including vaginal micronized progesterone.
- Evaluation of treatment protocols for early pregnancy complications.
Main Results:
- The totality of evidence suggests potential benefits of vaginal micronized progesterone.
- Women with a history of miscarriage and early pregnancy bleeding may benefit.
- Both natural and synthetic progestogens have been investigated.
Conclusions:
- Vaginal micronized progesterone is indicated for women with threatened miscarriage and a history of recurrent miscarriage.
- Further clinical implications of progesterone supplementation are discussed.
- Evidence supports progesterone use in specific early pregnancy scenarios.
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