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Updated: Dec 7, 2025
Chondrogenic Pellet Formation from Cord Blood-derived Induced Pluripotent Stem Cells
Published on: June 19, 2017
Expansion and Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells
Roberto Narcisi1, Wendy J L M Koevoet2, Gergo J V M van Osch3,2
1Department of Orthopedics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. n.narcisi@erasmus.nl.
Abstract:
Human bone marrow-derived mesenchymal stem/stromal cells (BM-MSC) are adult multipotent progenitor cells that can be isolated from bone marrow. BM-MSCs have the ability to be expanded and differentiated into the chondrogenic lineage in vitro. Here we describe a standardized method to expand and chondrogenically differentiate human BM-MSCs, highlighting how to overcome technical challenges and indicating the most common readout parameters to evaluate the chondrogenic differentiation capacity.
