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Mesenchymal stem cell therapies for COVID-19: Current status and mechanism of action

Somaye Sadeghi1, Sara Soudi2, Abbas Shafiee3

  • 1Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Life Sciences
|September 26, 2020
PubMed

Insights

Mesenchymal stem cells (MSCs) show promise for treating COVID-19 by regenerating tissue and reducing harmful inflammation. Clinical trials are exploring MSC-based therapies to address the urgent need for effective COVID-19 treatments.

Area of Science:

  • Immunology
  • Regenerative Medicine
  • Virology

Background:

  • COVID-19, a global health emergency, lacks effective treatments or vaccines.
  • Mesenchymal stem cells (MSCs) are recognized for their regenerative and immunomodulatory properties.

Purpose of the Study:

  • To review the potential therapeutic mechanisms of MSCs for COVID-19.
  • To summarize ongoing clinical trials investigating MSC-based COVID-19 treatments.

Main Methods:

  • Literature review of MSC mechanisms in tissue repair and immune modulation.
  • Survey of current clinical trials on MSCs for COVID-19.

Main Results:

  • MSCs can promote tissue regeneration and suppress cytokine storms associated with severe COVID-19.
  • MSCs have demonstrated potential in preventing cell death and inhibiting tissue fibrosis.

Conclusions:

  • MSCs offer a promising therapeutic avenue for COVID-19 due to their multifaceted biological effects.
  • Further research and clinical trials are essential to establish MSC-based therapies for COVID-19 patients.
Keywords:
Cell therapyClinical trialsCoronavirusCytokine stormImmunomodulatory effects

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