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Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Single Nucleotide Polymorphisms-SNPs01:05

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Related Experiment Video

Updated: Dec 7, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
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COVID-2019 - A comprehensive pathology insight.

Chandrakumar Shanmugam1, Abdul Rafi Mohammed2, Swarupa Ravuri3

  • 1Department of Pathology, RVM Institute of Medical Sciences & Research Center (KNR University of Health Sciences) Laxmakkapally, Mulugu, Siddipet Dist., Telangana, 502279, India.

Pathology, Research and Practice
|September 26, 2020
PubMed
Summary

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes COVID-19, impacting lungs and potentially other organs. This review details COVID-19 pathology and pathogenesis for therapeutic target development.

Keywords:
AFOPARDSCOVID-19PathologySARS CoV-2Therapeutic targets

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Area of Science:

  • Pathology
  • Virology
  • Pulmonology

Background:

  • COVID-19, caused by SARS-CoV-2, is a contagious RNA virus impacting respiratory health.
  • Severe cases manifest as pneumonia and respiratory failure, requiring mechanical ventilation.
  • Extrapulmonary symptoms (gastrointestinal, cardiac, neurologic) can occur.

Purpose of the Study:

  • To provide a pathology-centered understanding of COVID-19.
  • To review the pathological features and pathogenesis of COVID-19.
  • To identify potential therapeutic targets based on pathogenetic pathways.

Main Methods:

  • Literature review focusing on pathological findings.
  • Analysis of histopathological data correlating with disease severity.
  • Examination of secondary organ involvement.

Main Results:

  • Lung pathology ranges from congestion to acute respiratory distress syndrome (ARDS) and acute fibrinous organizing pneumonia (AFOP).
  • Disease severity correlates with observed histopathological changes.
  • Secondary involvement of organs like the liver and kidneys is noted.

Conclusions:

  • Understanding COVID-19 pathology is crucial for managing the disease.
  • Pathogenesis insights are vital for developing effective therapeutic strategies.
  • Further research into pathological features can guide future treatments.