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Updated: Dec 7, 2025

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
Published on: July 1, 2018
TRICking SOCE into altered oscillations
1Molecular Biophysics, Center of Integrative Physiology and Molecular Medicine (CIPMM), Bld 48, Saarland University, 66421, Homburg, Germany.
Abstract:
Defective ER/SR-cytosol Ca2+ cycling is associated with increased ER stress, pathological heart conditions and muscular defects. Within the SR, ryanodine receptor 2 (RyR2) is required for excitation/contraction coupling. Ca2+ release from the SR is counterbalanced by K+ influx through trimeric intracellular cation (TRIC) channels to maintain ER/SR polarity. New functions of TRIC channels have been discovered.
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