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Recent progress on nanoparticles for targeted aneurysm treatment and imaging
Nisakorn Yodsanit1, Bowen Wang2, Yi Zhao1
1Department of Biomedical Engineering, And Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
Biomaterials
|September 26, 2020
Summary
Nanoparticles offer promising therapeutic and diagnostic strategies for abdominal aortic aneurysms (AAAs). This review explores their potential in managing this life-threatening condition.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cardiovascular Research
Background:
- Abdominal aortic aneurysm (AAA) is a dangerous aortic dilatation with high mortality upon rupture.
- Excessive inflammation and extracellular matrix degradation characterize AAA pathology.
- Current treatments necessitate advanced methods to prevent AAA rupture.
Purpose of the Study:
- To review the progress, limitations, and future prospects of nanoparticle (NP) applications in abdominal aortic aneurysms (AAAs).
- To highlight the potential of NPs in therapeutic, diagnostic, and theranostic applications for AAA.
- To discuss NP modifications for improved targeting, imaging, and biocompatibility in AAA contexts.
Main Methods:
- Review of preclinical and clinical studies on NP applications in AAA.
- Analysis of NP strategies targeting inflammatory cells and extracellular matrix (ECM) in experimental AAA models.
- Examination of NP-based drug delivery, biomolecule encapsulation, and enhanced imaging for AAA monitoring.
Main Results:
- NPs show potential for targeted drug delivery and biomolecule encapsulation in AAA.
- NP-based imaging can enhance monitoring of AAA progression.
- Modifiable NP properties improve lesion targeting, detectability, biocompatibility, and circulation time.
Conclusions:
- Nanoparticles represent a promising avenue for developing novel therapeutic and diagnostic tools for AAA.
- Further research is needed to overcome limitations and fully realize the potential of NPs in clinical AAA management.
- NP technology offers versatile solutions for addressing the challenges posed by abdominal aortic aneurysms.
