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Updated: Dec 7, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
Current Techniques for Complex Phenotypes: GWAS of the Electrocardiogram
1Integrative Biology, Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA 02139, USA.
Abstract:
By sampling 500 time points of an electrocardiogram (ECG) trace in a genome-wide association study (GWAS), Verweig et al. identified novel correlates for cardiac dysfunction. Clustering of SNPs based on their impact at all time points revealed natural sets of SNPs with similar effects and mechanisms. Similar approaches may be applicable to other quantitative, time-ordered traits.
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