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Updated: Dec 7, 2025

In vitro Functional Characterization of Mouse Colorectal Afferent Endings

In vitro Functional Characterization of Mouse Colorectal Afferent Endings

Published on: January 21, 2015

Sympathetic Input to Multiple Cell Types in Mouse and Human Colon Produces Region-Specific Responses.

Kristen M Smith-Edwards¹, Brian S Edwards¹, Christina M Wright²

¹Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, Pennsylvania; Center for Neuroscience at the University of Pittsburgh, Pittsburgh, Pennsylvania.

Gastroenterology

|September 27, 2020

Summary

This summary is machine-generated.

Sympathetic neurons differentially control proximal and distal colon activity and motility by influencing both nerve and non-nerve cells. This study reveals region-specific neural regulation impacting digestive health.

Keywords:

GCaMP Gastrointestinal Interstitial Cells of Cajal Platelet-Derived Growth Factor Receptor–α

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Area of Science:

Neurogastroenterology
Autonomic Nervous System Regulation
Digestive Physiology

Background:

The colon's function relies on intrinsic and extrinsic neurons.
Sympathetic input influences colon motility via myenteric neurons.
Sympathetic transmitters may affect non-neuronal cells like glia and immune cells.

Purpose of the Study:

Investigate how sympathetic neurons modulate colon function.
Determine sympathetic-induced changes on myenteric circuit activity.
Explore sympathetic regulation of non-neuronal cells in the colon.

Main Methods:

Anatomical tracing and immunohistochemistry in mice.
Optogenetic calcium imaging (GCaMP, channelrhodopsin) in mice.
Colon motility studies in mice and single-cell RNA sequencing in human colon.

Main Results:

Sympathetic neurons innervate proximal and distal colon, interacting with diverse cell types.
Sympathetic nerve stimulation alters neural and non-neuronal cell activity in a region-specific manner.
Observed cellular activity changes correlate with distinct motility patterns in proximal and distal colon.

Conclusions:

Sympathetic neurons differentially regulate neuronal and non-neuronal cell activity in the proximal and distal colon.
These region-specific regulations promote distinct motility patterns, reflecting functional specialization.
Findings highlight the translational relevance of mouse models for human colon physiology.