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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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P53 in skin cancer: From a master player to a privileged target for prevention and therapy

J B Loureiro1, M Abrantes2, P A Oliveira3

  • 1LAQV/REQUIMTE, Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

Biochimica Et Biophysica Acta. Reviews on Cancer
|September 27, 2020
PubMed

Insights

Skin cancer (SC) incidence is rising globally. This review explores p53 protein

Area of Science:

  • Oncology
  • Dermatology
  • Molecular Biology

Background:

  • Rising global incidence of skin cancer (SC) necessitates novel therapeutic and preventive strategies.
  • Existing treatments face challenges with side effects and resistance mechanisms.
  • The p53 tumor suppressor protein plays a crucial role in skin carcinogenesis.

Purpose of the Study:

  • To review the role of p53 in melanoma and non-melanoma skin carcinogenesis.
  • To highlight the therapeutic potential of p53-targeting drugs for SC.
  • To discuss p53 mutations as targets for future SC prevention.

Main Methods:

  • Literature review of studies on p53 in skin cancer.
  • Analysis of therapeutic outcomes with p53-activating drugs.
  • Exploration of p53 mutations in photocarcinogenesis.

Main Results:

  • p53-activating drugs show encouraging outcomes in SC treatment, both alone and in combination therapies.
  • Targeting p53 mutations offers a perspective for future SC preventive approaches.
  • Evidence supports the clinical relevance of p53 in SC development and treatment.

Conclusions:

  • p53-targeting agents represent promising alternatives for SC therapy and prevention.
  • Further research can facilitate the clinical translation of p53-activating drugs in precision medicine for SC.
  • This review provides critical insights into SC prevention and therapy, focusing on the p53 pathway.
Keywords:
ChemopreventionChemotherapyMelanomaNon-melanoma skin cancerp53

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