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Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection
Published on: July 5, 2024
Gastric neuroendocrine tumor with Helicobacter pylori-associated chronic gastritis
Giovanni Serio1, Armando Dell'Anna2, Anna Debenedittis1
1Unit of Anatomic Pathology, Vito Fazzi Hospital, Lecce, Italy.
Introduction:
Development of gastric neuroendocrine neoplasms in subjects infected with Helicobacter pylori is rare and it occurs through pathogenetic mechanisms related to gastrin.
Presentation Of Case:
We report a case of gastric neuroendocrine tumor in a patient infected with Helicobacter pylori and normal gastrin levels. He was treated by endoscopic mucosal dissection after eradication of Helicobacter pylori infection. Histologically the tumor was consistent with a grade 2 well differentiated neuroendocrine tumor. It was characterized by the presence of lymphoid aggregates around and inside the neoplasia.
Discussion:
Helicobacter pylori-associated chronic gastritis can rarely cause the development of gastric neuroendocrine tumors through mechanisms unrelated to gastrin.
Conclusion:
The one related to a chronic Helicobacter pylori infection may be considered a distinct type of gastric neuroendocrine tumor.
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