Related Experiment Video
Updated: Dec 7, 2025
Author Spotlight: Bridging Gaps in Anatomy and Establishing a Foundation for Algorithmic Studies
Published on: December 15, 2023
Pediatric choroid plexus papilloma arising from the cerebellopontine angle: systematic review with illustrative case
Mairre James S Gaddi1, Jeffrey I Lappay2, Kevin Ivan P Chan3
1Division of Neurosurgery, Department of Neurosciences, University of the Philippines - Philippine General Hospital, Manila, Philippines. msgaddi1@up.edu.ph.
Insights
Pediatric choroid plexus papillomas in the cerebellopontine angle are rare. This systematic review of 11 cases shows surgical resection leads to excellent outcomes and recovery for children.
Area of Science:
- Neuro-oncology
- Pediatric Neurosurgery
- Central Nervous System Tumors
Background:
- Choroid plexus tumors are uncommon intraventricular neoplasms originating from the choroid plexus.
- Choroid plexus papillomas in the cerebellopontine angle are exceptionally rare in children, typically affecting adults.
Purpose of the Study:
- To systematically review pediatric choroid plexus papillomas in the cerebellopontine angle.
- To analyze clinical presentation, imaging, management, and outcomes in this rare pediatric population.
Main Methods:
- Systematic review of case reports and series from SCOPUS and PubMed adhering to PRISMA guidelines.
- Inclusion of one additional case managed at the reporting center for a total of eleven cases.
Main Results:
- Eleven pediatric cases of cerebellopontine angle choroid plexus papillomas were identified (median age 8 years, female predilection).
- Common symptoms included headache, cerebellar signs, and cranial nerve palsies (median duration 4 months).
- All patients underwent surgery with gross total excision achieved in most; no deaths reported at 12-month follow-up, with significant neurologic recovery.
Conclusions:
- Pediatric choroid plexus papillomas in the cerebellopontine angle are rare but important differential diagnoses.
- Complete surgical resection is the primary treatment modality.
- Excellent outcomes and recovery are achievable with timely surgical intervention.
Introduction:
Choroid plexus tumors are uncommon intraventricular tumors that develop from the choroid plexus of the central nervous system. Choroid plexus papillomas arising from the cerebellopontine angle have been reported to almost exclusively occur in adults and are rarely found in children.
Methods:
We report a systematic review conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines of SCOPUS and PubMed databases for case reports and case series of choroid plexus papillomas arising in the cerebellopontine angle in the pediatric population and discuss clinical presentation, imaging features, management options, and outcomes. We also report a case managed at our center.
Results:
Ten cases of pediatric choroid plexus papillomas arising in the cerebellopontine angle were identified from the systematic review in addition to the case reported here, resulting in a total of eleven cases. The patients' median age was 8 years with a slight female sex predilection (1.2:1). Patients most commonly presented with headache, cerebellar signs, and cranial nerve palsies with median duration of symptoms at 4 months. All patients underwent surgical treatment with majority achieving gross total excision. No deaths were reported at median follow-up of 12 months. Complete neurologic recovery was attained in seven cases while partial recovery was seen in two cases.
Conclusion:
Choroid plexus papillomas found in the cerebellopontine angle in the pediatric population are extremely rare but they should be considered in the differential diagnosis. Complete surgical resection is the mainstay of treatment with excellent outcomes achievable in majority of patients.
More Related Videos
03:13Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy
Published on: June 28, 2024
09:58A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
Published on: May 6, 2016