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Eculizumab treatment for renal failure in a pediatric patient with COVID-19

Ruchi Mahajan1, Marissa Lipton1, Larisa Broglie2

  • 1Division of Pediatric Nephrology, Columbia University Vagelos College of Physicians and Surgeons, 622 West 168th Street, PH 17-102B, New York, NY, 10032, USA.

Journal of Nephrology
|September 27, 2020
PubMed

Insights

COVID-19 can cause kidney failure in children through thrombotic microangiopathy. A pediatric case of COVID-19 with renal failure was successfully treated with eculizumab, highlighting a potential therapeutic approach.

Area of Science:

  • Pediatric Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Acute kidney injury (AKI) is reported in adult COVID-19 patients, but data on pediatric renal complications remain scarce.
  • COVID-19-related kidney injury is multifactorial, involving complement dysregulation and thrombotic microangiopathy.
  • Thrombotic microangiopathy (TMA) is a serious condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ damage.

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