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The Malpighi lecture. From 'Porositates carnis' to cellular microcirculation
International Journal of Microcirculation, Clinical and Experimental
|January 1, 1987
Summary
Capillary transport mechanisms are evolving. Recent electrophysiological studies reveal rapid permeability changes in endothelial cells, possibly linked to calcium signaling and vasodilation.
Area of Science:
- Physiology
- Microcirculation Research
- Endothelial Cell Biology
Background:
- The function of capillaries, specifically solute transport between blood and tissue, was conceptualized nearly 200 years after Malpighi's discovery.
- Pioneering work by Carl Ludwig, Christian Bohr, and August Krogh established early models of transcapillary diffusion.
- The two-pore model became the dominant paradigm, viewing hydrophilic molecule transport as a paracellular process.