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Related Concept Videos

Mutations01:35

Mutations

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Nucleotide Excision Repair01:38

Nucleotide Excision Repair

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DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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Related Experiment Video

Updated: Dec 7, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Radiation induced pemphigoid disease.

Jihyun Kim1, Taewon Jung1, Kyongjin Kim1

  • 1Department of Obstetrics and Gynecology, Presbyterian Medical Center, Jeonju, Korea.

Obstetrics & Gynecology Science
|September 28, 2020
PubMed
Summary

Radiation therapy can cause skin issues. This case report highlights pemphigoid disease, a rare skin condition, developing after cancer treatment, emphasizing diagnostic vigilance.

Keywords:
Endometrial cancerPemphigoidRadiation therapy

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Area of Science:

  • Oncology
  • Dermatology
  • Radiotherapy

Background:

  • Radiation therapy can lead to acute and chronic skin complications at the treatment site.
  • Radiation dermatitis is a common side effect, typically managed with topical treatments.
  • Pemphigoid disease, a rare blistering skin disorder, can mimic other conditions and rarely occurs post-radiotherapy.

Purpose of the Study:

  • To report a rare case of pemphigoid disease developing after radiation therapy for endometrioid/clear cell carcinoma.
  • To emphasize the importance of careful diagnosis when skin lesions appear in radiotherapy sites, especially when they resemble other conditions.
  • To highlight the diagnostic challenges and timely treatment considerations for pemphigoid disease in this context.

Main Methods:

  • Case report detailing a patient with endometrioid/clear cell carcinoma.
  • Review of clinical presentation and diagnostic process for a patient who developed skin lesions post-radiotherapy.
  • Analysis of the temporal relationship between radiation therapy and the onset of pemphigoid disease.

Main Results:

  • A patient with endometrioid/clear cell carcinoma developed pemphigoid disease in the radiotherapy site.
  • The onset of pemphigoid disease occurred more than six months after radiation therapy.
  • The clinical presentation of pemphigoid disease mimicked other skin conditions, necessitating careful differential diagnosis.

Conclusions:

  • Pemphigoid disease is a rare but possible complication following radiotherapy.
  • Delayed diagnosis of pemphigoid disease can occur due to its similar presentation to other skin conditions.
  • Vigilance in diagnosis and timely treatment are crucial for managing pemphigoid disease in patients with a history of radiotherapy.