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Recent developments in the pathobiology of lung myofibroblasts

Dingyuan Jiang¹, Tapan Dey², Gang Liu²

¹Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital; National Clinical Research Center for Respiratory Diseases , Beijing, China.

Expert Review of Respiratory Medicine

|September 28, 2020

Summary

Lung myofibroblasts drive lung fibrosis. Recent research highlights their origins, regulation, and potential as therapeutic targets, offering new treatment strategies for this disease.

Area of Science:

Pulmonary Medicine
Cell Biology
Fibrosis Research

Background:

Myofibroblasts are central to lung fibrosis pathogenesis.
Understanding myofibroblast behavior is key to developing effective treatments.

Purpose of the Study:

To review recent advances in lung myofibroblast pathobiology.
To explore novel therapeutic strategies targeting lung myofibroblasts.

Main Methods:

Literature review of studies published between 2010 and 2020.
Utilized PubMed database with specific keywords related to lung myofibroblasts and fibrosis.

Main Results:

Advances in cell lineage characterization and single-cell RNA sequencing (scRNA-seq) clarify myofibroblast origins and heterogeneity.
Cellular metabolism is identified as a critical regulator of myofibroblast phenotype and a potential therapeutic target.

Conclusions:

Targeting lung myofibroblasts offers promising therapeutic avenues for lung fibrosis.
Emerging insights into myofibroblast origins and metabolism are crucial for future treatment development.

Keywords:

Lung fibrosis apoptosis cellular metabolism glutaminolysis glycolysis myofibroblast resolution senescence α-SMA

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