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Cardio-Ankle Vascular Index Predicts Post-Discharge Stroke in Patients with Heart Failure

Yu Sato1, Akiomi Yoshihisa1,2, Yasuhiro Ichijo1

  • 1Department of Cardiovascular Medicine, Fukushima Medical University.

Journal of Atherosclerosis and Thrombosis
|September 28, 2020
PubMed

Insights

The cardio-ankle vascular index (CAVI) can independently predict stroke in heart failure (HF) patients. A high CAVI (≥9.64) indicates a significantly increased risk of post-discharge stroke.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Clinical Cardiology

Background:

  • Heart failure (HF) is a significant risk factor for cerebrovascular events.
  • Predictive markers for stroke in HF patients are crucial for risk stratification and management.

Purpose of the Study:

  • To evaluate the cardio-ankle vascular index (CAVI) as a predictor of stroke in patients with heart failure (HF).

Main Methods:

  • A prospective observational study of 557 hospitalized HF patients who underwent CAVI measurement.
  • Patients were categorized into high-CAVI (≥9.64) and low-CAVI (<9.64) groups based on ROC analysis.
  • Post-discharge stroke rates were compared between groups using Kaplan-Meier and Cox proportional hazard analyses.

Main Results:

  • The high-CAVI group exhibited higher prevalence of older age, male sex, coronary artery disease, and diabetes mellitus.
  • Kaplan-Meier analysis revealed a significantly higher post-discharge stroke rate in the high-CAVI group (log-rank P=0.005).
  • Multivariate analysis identified high CAVI as an independent predictor of stroke (adjusted hazard ratio: 3.599).

Conclusions:

  • The cardio-ankle vascular index (CAVI) is an independent predictor of stroke in patients diagnosed with heart failure.
  • Elevated CAVI levels in HF patients signify an increased risk for future stroke events.
Abstract

Keywords:
Arterial stiffnessAtherosclerosisCardio-ankle vascular indexHeart failureStroke

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