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Risk of Lymphoma Associated with Anti-TNF Therapy in Patients with Inflammatory Bowel Disease: Implications for

Jessica Dahmus1, Michelle Rosario1, Kofi Clarke1

  • 1Gastroenterology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA.

Clinical and Experimental Gastroenterology
|September 28, 2020
PubMed

Anti-tumor necrosis factor alpha (ATA) therapy plays a significant role in the treatment of moderate to severe inflammatory bowel disease (IBD). There are concerns regarding risks associated with their use, including malignancy and, specifically, lymphoma. Many previous studies have sought to determine whether there is a true link between ATA therapy in IBD and development of lymphoma. However they have been hindered by short follow-up times, few cases, and confounding factors such as previous thiopurine exposure. This review seeks to update the literature by evaluating more recent studies assessing the link between ATA monotherapy and lymphoma development. It also summarizes findings of those studies and provides additional clinical guidance pertaining to this class of biologic therapy.

Keywords:
Crohn’s diseasebiologicscancerhepatosplenic T-cell lymphomamalignancyulcerative colitis

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