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Contrast-Sensitivity Function and Photo Stress-Recovery Time in Prediabetes
Prema K Chande1, Rajiv Raman2, Preethi John3
1Chitkara School of Health Sciences and Lotus College of Optometry, Mumbai, India.
Clinical Optometry
|September 28, 2020
Summary
Prediabetes is linked to reduced contrast sensitivity and delayed macular function, indicating early visual changes. These findings suggest potential microvascular damage before diabetes diagnosis.
Area of Science:
- Ophthalmology
- Endocrinology
- Visual Neuroscience
Background:
- Prediabetes represents a critical window for early intervention in metabolic health.
- Ocular health can serve as an early indicator of systemic metabolic dysfunction.
Purpose of the Study:
- To evaluate contrast sensitivity function (CSF) and photo stress-recovery time (PSRT) in individuals with prediabetes.
- To identify potential early ocular changes associated with prediabetes.
Main Methods:
- A cross-sectional observational study included 70 participants aged 25-45, categorized into normal, prediabetic, and diabetic groups based on HbA1C.
- Participants underwent comprehensive eye exams, excluding those with retinopathy, cataract, glaucoma, or high myopia. Best-corrected visual acuity was 0 logMAR.
- CSF was measured using the Pelli-Robson chart, and PSRT was assessed via direct ophthalmoscopy.
Main Results:
- Mean CSF was significantly lower in prediabetic (1.64±0.11 log units) and diabetic (1.61±0.08 log units) groups compared to the normal group (1.71±0.10 log units) (p<0.001).
- PSRT was significantly delayed in prediabetic (41.63 seconds) and diabetic (47.77 seconds) groups compared to the normal group (35.80 seconds) (p<0.001).
Conclusions:
- Reduced CSF and delayed PSRT in prediabetes suggest early visual system alterations.
- These ocular changes may provide clinical insights into pre-diabetic microvascular damage.
- Further research with larger cohorts is recommended to validate these findings.
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