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Clinical Challenges in an Outbreak of COVID-19 in Wuhan, China: Concerns from Frontiers

Yao Wang1, Luwen Wang1, Xun Li1

  • 1Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China.

Current Infectious Disease Reports
|September 28, 2020
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, spreading via respiratory droplets. While diagnostic methods improve, specific antiviral treatments are lacking, necessitating focus on managing cytokine storms.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • The emergence of SARS-CoV-2 in Wuhan, China, led to a global pandemic.
  • COVID-19 exhibits diverse clinical presentations, from mild to critical illness.

Purpose of the Study:

  • To review COVID-19 transmission, risk factors, diagnosis, pathogenesis, and treatments.
  • To inform prevention and treatment strategies for COVID-19.

Main Methods:

  • Literature review of current research on COVID-19.
  • Synthesis of information on transmission, diagnostics, and therapeutics.

Main Results:

  • COVID-19 is highly contagious, primarily through respiratory transmission.
  • Diagnosis relies on viral nucleic acid tests, clinical symptoms, CT scans, and biochemical markers.
  • Cytokine storm is a critical factor in severe COVID-19 progression and mortality.

Conclusions:

  • Diagnostic techniques for SARS-CoV-2 are advancing.
  • Specific antiviral drugs for COVID-19 are still under development.
  • Management of cytokine storm is crucial for treating severe COVID-19 cases.
Abstract

Keywords:
COVID-19Clinical challengesSARS-CoV-2

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