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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action
Bahare Salehi1,2, Javad Sharifi-Rad3, Francesca Cappellini4
1Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran.
Abstract:
Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and antiinflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic and anticancer activities, and their role in cardiovascular and neuroprotective prevention. This review aims to comprehensively analyze different studies performed on this class of compounds, their bioavailability and their therapeutic potential. An in-depth look in preclinical, in vitro and in vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, antiobesity as well as their antidiabetes and anticancer effects.
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