Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

1.5K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.5K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

2.5K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.5K
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

181
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
181
Autoimmune Disorders01:29

Autoimmune Disorders

1.2K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.2K
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

132
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
132
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

541
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
541

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of an immunogenic epitope from RASGRP2 with specificity for HLA-DR15 in multiple sclerosis.

Journal of neuroimmunology·2026
Same author

A tailored cognitive behavioural therapy intervention for depression in those newly diagnosed with multiple sclerosis (ACTION-MS): A randomised, assessor-blinded, active comparator trial.

Journal of affective disorders·2026
Same author

Immune response to adeno-associated viral vectors in a human iPSC-derived microglia chimeric mouse model.

Cell reports methods·2026
Same author

Neurofilament Light Chain Concentration in the Prediction of Treatment Response in Multiple Sclerosis.

European journal of neurology·2026
Same author

Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents.

Neuron·2026
Same author

In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis.

Science translational medicine·2026

Related Experiment Video

Updated: Dec 7, 2025

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

4.3K

Multiple Sclerosis as a Syndrome-Implications for Future Management.

Christopher M Dwyer1,2, Linda Thien-Trang Nguyen1, Luke M Healy3

  • 1Florey Institute of Neuroscience and Mental Health, Florey Department, The University of Melbourne, Parkville, VIC, Australia.

Frontiers in Neurology
|September 28, 2020
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) is a syndrome, not a single disease, due to diverse mechanisms causing its symptoms. Personalized management will utilize genetic and molecular data for better patient stratification and treatment.

Keywords:
demyelinationinnate immunitymultiple sclerosispathophysiologysyndrome

More Related Videos

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.5K
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.5K

Related Experiment Videos

Last Updated: Dec 7, 2025

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

4.3K
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.5K
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.5K

Area of Science:

  • Neuroimmunology
  • Genetics
  • Personalized Medicine

Background:

  • Multiple sclerosis (MS) is clinically characterized by a constellation of symptoms and signs.
  • Current understanding often treats MS as a singular disease entity.

Purpose of the Study:

  • To propose that multiple sclerosis (MS) is best characterized as a syndrome.
  • To explore diverse pathogenetic mechanisms underlying MS.
  • To advocate for molecular profiling in patient stratification and personalized management.

Main Methods:

  • Review of cellular mechanisms causing inflammatory demyelination.
  • Analysis of genomic data for identifying phenocopies, especially in primary progressive MS.
  • Examination of molecular profiling for patient stratification.

Main Results:

  • Different pathogenetic mechanisms can lead to the MS clinical presentation.
  • Genomics aids in identifying phenocopies, particularly in primary progressive MS.
  • Molecular profiling, including HLA and MERTK interactions, enables meaningful patient stratification.

Conclusions:

  • Multiple sclerosis (MS) is a syndrome with heterogeneous underlying causes.
  • Genomic and molecular profiling are crucial for accurate patient stratification.
  • A personalized approach integrating genetic, molecular, and cellular data will guide MS management.