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RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance
Jianmin Chen1, Gareth S D Purvis2, Debora Collotta3
1Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Frontiers in Immunology
|September 28, 2020
Summary
Specialized pro-resolving mediators (SPMs) like RvE1 are reduced in sepsis hearts, causing cardiac dysfunction. RvE1 treatment attenuated this dysfunction and enhanced bacterial clearance in mice.
Area of Science:
- Cardiovascular Biology
- Immunology
- Pharmacology
Background:
- Sepsis-induced cardiac dysfunction is a major cause of mortality.
- Specialized pro-resolving mediators (SPMs) are crucial for inflammation resolution.
- SPMs show altered expression in sepsis patients.
Purpose of the Study:
- To investigate SPM levels in the septic murine heart.
- To determine the therapeutic potential of RvE1 in sepsis-induced cardiac dysfunction.
Main Methods:
- Polymicrobial sepsis induced by cecal ligation and puncture (CLP) in mice.
- Echocardiography to assess cardiac function.
- LC-MS/MS lipid mediator profiling of heart tissue.
- Treatment with synthetic RvE1 post-CLP.
Main Results:
- CLP induced significant cardiac systolic dysfunction.
- SPMs, especially RvE1, were significantly reduced in septic hearts.
- RvE1 treatment attenuated cardiac dysfunction, modulated inflammatory pathways, and reduced bacterial load.
Conclusions:
- Cardiac SPMs, particularly RvE1, are depleted during polymicrobial sepsis.
- RvE1 therapy mitigates sepsis-induced cardiac dysfunction by modulating inflammation and enhancing bacterial clearance.
- RvE1 shows therapeutic promise for sepsis sequelae.
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