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3D bioprinting and craniofacial regeneration
Ruby Dwivedi1, Divya Mehrotra1
1Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George's Medical University, Lucknow, Uttar Pradesh, India.
Journal of Oral Biology and Craniofacial Research
|September 28, 2020
Summary
Three-dimensional (3D) bioprinting shows promise for craniofacial regeneration, utilizing bioinks with biomaterials and stem cells. Ongoing research aims to refine techniques for successful bone and cartilage tissue engineering.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Tissue Engineering
Background:
- Craniofacial tissues are structurally and functionally complex.
- Three-dimensional (3D) bioprinting offers a potential solution for creating functional craniofacial tissues and organs.
- This technology is particularly relevant for *in vivo* applications in craniofacial bone and cartilage regeneration.
Purpose of the Study:
- To review the emerging field of 3D bioprinting.
- To explore its applications in craniofacial bone and cartilage regeneration.
Main Methods:
- Comprehensive literature searches were conducted across major scientific databases (PubMed, Google Scholar, Medline, Embase, Science Direct).
- Keywords included terms related to craniofacial regeneration and 3D bioprinting technologies.
- Exclusion criteria were applied to remove reviews and duplicate articles.
Main Results:
- An initial search yielded 476 articles, reduced to 108 after excluding reviews.
- Further screening and reference checking resulted in a final selection of 68 articles for the review.
Conclusions:
- Successful craniofacial tissue regeneration has been achieved using 3D bioprinting with various bioinks, biomaterials, and stem cells.
- Despite progress, continued efforts are necessary to optimize 3D bioprinting for desired craniofacial bone and cartilage regeneration outcomes.
