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Minimally Invasive Platforms in Biosensing.

Prem C Pandey1, Govind Pandey2, Roger J Narayan3

  • 1Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, India.

Frontiers in Bioengineering and Biotechnology
|September 28, 2020
PubMed
Summary
This summary is machine-generated.

This review explores minimally invasive biosensing platforms, focusing on microneedle technology for efficient body fluid analysis. These advancements enhance clinical diagnostics by enabling sensitive detection with minimal sample volumes.

Keywords:
fluorescent biosensorsluminescent sensorsmicrofabricationmicrofluidicsmicroneedletransdermal biosensing

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Clinical Diagnostics

Background:

  • Effective clinical diagnostics rely on sensing components interacting with body fluids.
  • Novel invasive and non-invasive sensing platforms are crucial for advancing healthcare.
  • Minimally invasive approaches offer advantages by requiring small body fluid volumes.

Purpose of the Study:

  • To review recent advancements in minimally invasive biosensing platforms.
  • To highlight innovations in microneedle-based biosensing for clinical diagnostics.
  • To discuss the structural and performance improvements in these novel sensing technologies.

Main Methods:

  • Review of recent scientific literature on minimally invasive biosensing.
  • Analysis of various approaches for generating platforms requiring small body fluid volumes.
  • Focus on microneedle technology and its application in biosensing.

Main Results:

  • Microneedle technology enables minimally invasive detection using small body fluid volumes.
  • Capillary action in microneedle-assisted biosensing facilitates analyte detection.
  • Recent innovations have improved the structure and performance of minimally invasive sensors.

Conclusions:

  • Minimally invasive biosensing, particularly using microneedles, is a promising area for clinical diagnostics.
  • These platforms offer efficient analyte detection with reduced sample requirements.
  • Continued innovation in sensor design and performance is expected to further enhance diagnostic capabilities.