Nucleic acid-based therapy for coronavirus disease 2019.

Area of Science:

• Biochemistry
• Molecular Biology
• Pharmacology

Background:

• COVID-19 pandemic caused by SARS-CoV-2 has led to a global health crisis.
• Existing treatments are insufficient, necessitating novel therapeutic strategies.
• SARS-CoV-2 shares similarities with SARS-CoV, suggesting potential cross-effectiveness of treatments.

Purpose of the Study:

• To review nucleic acid-based molecules as potential therapeutic agents for COVID-19.
• To explore the application of these molecules in vaccine development for SARS-CoV-2.
• To highlight advancements in nucleic acid therapeutics for targeted drug delivery and gene regulation.

Main Methods:

• Literature review of scientific studies on nucleic acid-based therapeutics.
• Analysis of research on molecules effective against SARS-CoV and their relevance to SARS-CoV-2.
• Evaluation of recent advancements in nucleic acid drug delivery and gene expression modulation.

Main Results:

• Nucleic acid-based molecules demonstrate potential as drug candidates against SARS-CoV-2.
• These molecules have shown efficacy against SARS-CoV, a related virus.
• Advancements enable safe and effective targeted drug delivery and gene expression regulation.

Conclusions:

• Nucleic acid-based biologically active molecules are promising for COVID-19 treatment and vaccine development.
• Targeted delivery and gene regulation capabilities enhance their therapeutic potential.
• Further research into these molecules could lead to effective interventions against SARS-CoV-2.