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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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Related Experiment Video

Updated: Dec 7, 2025

Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome
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Skeletal Muscle Density and Cognitive Function: A Cross-Sectional Study in Men.

Sophia X Sui1,2, Lana J Williams3, Kara L Holloway-Kew3

  • 1Deakin University, IMPACT Institute, Geelong, VIC, Australia. ssui@deakin.edu.au.

Calcified Tissue International
|September 28, 2020
PubMed
Summary

Higher skeletal muscle density is linked to better psychomotor function and visual learning in older men. This association appears independent of body fat and inflammation, suggesting muscle quality is key for cognitive health.

Keywords:
Cognitive domainsMuscle densityOlder menPeripheral quantitative computed tomographyPopulation-based study

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Area of Science:

  • Gerontology
  • Muscle Physiology
  • Cognitive Neuroscience

Background:

  • Skeletal muscle density, a marker of fatty infiltration, and cognitive function decline with age.
  • Factors like body fat, inflammation, and lifestyle may influence both muscle and cognitive health.

Purpose of the Study:

  • To investigate the relationship between skeletal muscle density and cognitive function in older men.
  • To explore the roles of body fat, inflammation, and lifestyle as potential confounders.

Main Methods:

  • Cross-sectional study of 281 men (60-95 years) from the Geelong Osteoporosis Study.
  • Muscle density measured by peripheral quantitative computed tomography (pQCT).
  • Cognitive function assessed using CogState Brief Battery (psychomotor function, visual identification/attention, visual learning, working memory).

Main Results:

  • Muscle density positively associated with psychomotor function (DET) and visual learning (OCL) after age adjustment.
  • Association between radial muscle density and DET was explained by TNF-α, while tibial muscle density and DET remained associated.
  • Education and physical activity influenced radial muscle density and DET.

Conclusions:

  • Skeletal muscle density is associated with specific cognitive domains (psychomotor function and visual learning) in older men.
  • The link between muscle density and cognition is not significantly explained by body fat mass or systemic inflammation.
  • Further research into the mechanisms linking muscle quality to cognitive health is warranted.