Zinc(II) complexes in diabetes management: Plant-derived phenolics as understudied promising ligands

Zinc mineral has been known as a supplement for diabetics due to its deficiency in diabetics. Its glycemic control and insulin mimetic properties have been reported. Thus, it has been complexed with numerous types of ligands to improve the glycemic control property of the ligands. Unfortunately, mostly synthetic ligands with little or no bioactive properties and toxicity concerns have been complexed with Zn, while plant-derived dietary phenolics have rarely been explored as ligand for Zn complexation, despite their medicinal credence and minimal toxicity concern. In this letter, plant-derived phenolics have been presented as promising ligands for Zn(II) in developing potent antidiabetic and antioxidative nutraceutical complexes with improved and multi-facet bioactivity profile, as well as minimal toxicity concerns. Thus, fostering the paradigm shift from synthetic medicine toward dietary and functional medicine. PRACTICAL APPLICATIONS: Potentially, complexing Zn(II) with bioactive plant-derived dietary phenolics could result in novel nutraceuticals and/or supplements with improved and multi-facet bioactivity profile, as well as minimal toxicity concerns.