Construction of Enzyme Nanoreactors to Enable Tumor Microenvironment Modulation and Enhanced Cancer Treatment

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Cancer Therapy

Background:

• Enzymes are crucial for biological functions and disease treatment.
• The tumor microenvironment (TME) often hinders cancer therapy effectiveness.
• Enzymes show potential in directly suppressing tumors and improving treatment outcomes by modulating the TME.

Purpose of the Study:

• To review chemical approaches for creating enzyme nanoreactors with retained catalytic activity and reduced immunogenicity.
• To discuss the application of these nanoreactors in modulating the TME.
• To provide perspectives on future developments for enhanced cancer treatment.

Main Methods:

• Summary of chemical synthesis strategies for enzyme nanoreactors.
• Discussion of nanoreactor applications in altering TME characteristics.
• Exploration of TME modulation for cancer therapy.

Main Results:

• Enzyme nanoreactors can be chemically constructed with preserved function and lower immunogenicity.
• These nanoreactors effectively attenuate tumor hypoxia and modulate the extracellular matrix.
• Applications include amplifying tumor oxidative stress for therapeutic benefit.

Conclusions:

• Enzyme nanoreactors offer a promising strategy for TME modulation in cancer treatment.
• Further development of these nanoreactors could significantly enhance therapeutic efficacy.
• Targeting the TME with enzyme nanoreactors represents a novel approach in oncology.